Nanopore Technology for Future Point-of-Care Testing (POCT): System Integration and Commercialization Prospects

Abstract

The potential applications and potential business applications for nanopore sensing systems in point-of-care tests (POCT) will be covered in detail in this paper. With the COVID-19 crisis exposing the limitations of traditional point-of-care testing methods like LFA in terms of awareness, nanopore technology, with its benefits of no tagging, real-time recognition, and single-molecule resolution, has developed into a potent candidate to bridge the gap between POCT and high-sensitivity lab testing. The paper introduces the fundamental principle of nanopore sensing and its two detection strategies, direct detection and carrier-controlled detection, which both apply to various complex sample environments. The article provides further details on the POCT system integration process, including the inclusion of high-speed and low-noise electrical equipment, a smooth link with smartphones and sky platforms, and the design of microfluidic chips for test pretreatment, flexible solid-state nanopore arrays, and system integration. The paper assesses the challenges faced during commercialization, such as sample interference, pore blockage, and technical bottlenecks caused by difficult economic noise. It looks forward to solving these problems through fresh materials, edge AI, and low-power devices. Ultimately, nanopore technology has much potential for quick, sensitive, and multi-target point-of-care testing in neighborhoods, pharmacies, homes, and even far-off places. It provides a crucial technological foundation for marketing distributed open health control.