Research Progress of Nanofibrous Scaffolds in Long Bone Treatment

Abstract

Currently, through electrospinning and solution blow molding techniques, new material bone scaffold nanofiber scaffolds have been developed for bone repair applications. The research background is rooted in the urgent need for bone injury treatment worldwide and the significant limitations of traditional metal-ceramic scaffolds, which have high infection and wear rates. This paper explores the methods and technical advantages and disadvantages of the two spinning techniques as well as their effects on fiber properties. Additionally, it discovers that the physical structural advantages of the nanofibers in the scaffolds can meet the simulated microenvironment of natural bone. Due to their unique fiber properties, they can significantly enhance the biocompatibility and wear resistance of the scaffolds. With the global digital development, nanofiber scaffolds can evolve towards an intelligent and personalized direction. By utilizing artificial intelligence and biosensing technologies, a more natural structural scaffold closer to the patient's own bone tissue can be created, thereby further improving the biocompatibility of the scaffolds and the regeneration effect of bone tissue.