The Effect of Kynureninase on Cancer Treatment

Abstract

At present, cancer is still one of the most common lethal diseases in human beings. The traditional treatment of cancer has great side effects on human body, and more advanced treatment schemes need to be found to improve the survival rate of cancer. Nowadays, immunotherapy and targeted therapy are very promising directions. In immunotherapy, most of them are immune checkpoint inhibitors, cancer vaccines, cell therapy, etc., and few biological enzymes have been applied in cancer treatment. This paper analyzes the research on kynureninase, and proves that kynurenine accumulation is one of the important factors that lead to the occurrence of tumors. Combined with kynureninase, it can have a significant effect in the treatment of large B16-F10 melanoma, 4T1 breast cancer or CT26 colon cancer tumors. It can provide reference for the future research of immunotherapy, and the source problem of kynureninase has not been solved. Future research can focus on the development and optimization of humanized enzyme.